Translational Pharmacology

We focus on the generation high quality pharmacokinetic (PK) data to help optimize drugs as antivirals and advance investigational compounds toward clinical candidacy.

Don Francis

Jeremiah Momper, PharmD, PhD
Principal Investigator
Associate Professor, Division of Pharmaceutical Sciences
Skaggs School of Pharmacy and Pharmaceutical Sciences
University of California, San Diego

Dr. Momper’s research focuses on the application of quantitative pharmacology approaches to optimize the development and clinical use of drugs.  He was previously the Commissioner’s Fellow in the Office of Clinical Pharmacology at the U.S. Food and Drug Administration.  Current research directions include evaluation of potential therapies for HIV infection in infants and pregnant women and the use of model-based methods to support scientific decision making in drug development. Dr. Momper directs the Translational Pharmacology and Bioanalysis Laboratory at UC San Diego concentrated on novel mass spectrometry-based analytical methods, in vitro ADME assays, and pre-clinical and clinical pharmacokinetic studies.

Dr. Rogawski, MD, Distinguished Professor of Neurology and Pharmacology and Affiliate Member of the UC Davis Center for Neuroscience.

Dr. Rogawski is Professor of Neurology and Pharmacology at the University of California, Davis School of Medicine. His research encompasses discovery of neurological therapeutics, characterization of drug mechanism, and early and later stage drug development. Dr. Rogawski is an elected fellow of the American Association for the Advancement of Science and was awarded the UC Davis Chancellor's Innovator of the Year Award for inventing the drug Zulresso™.

He also directs the yearly NIH course on drug discovery for neurotherapeutics and has been a member of the FDA panel.

DSC_0116-white-coat-retouch-GREY-BACK.tif
IMG_5470 (1).JPG
Chun-Yi “Jimmy” Wu, PhD
Director, UC Davis Bioanalysis and Pharmacokinetics Core Facility, Department of Neurology
University of California, Davis

Expert in bioanalysis of animal and patient samples, pharmacokinetic analysis and formulation studies.

 

The facility contains a Waters Acquity-I class UPLC and Waters Xevo TQ-S triple quadrupole MS/MS with ESI and APCI/APPI ionization sources. Pharmacokinetic analyses are performed with Centara Phoenix WinNonlin 7.0, an industry-standard and FDA-compliant software system for pharmacokinetics. 

The facility conducts analytical services for the UC Davis Good Manufacturing Practices Laboratory, allowing the production of drug products meeting FDA, USP and State of California Requirements.