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Most recent publications

The UC-NL ATTACK team has invested all possible resources to help solve the current COVID-19 crisis and be better prepared for the next pandemic. This is also illustrated by major publications in high impact journals. Below are listed our most recent published research. Do not hesitate to contact the authors for further information and possible collaborations. 


1. Chaturvedi S, Vasen G, Pablo M, Chen X, Beutler N, Kumar A, Tanner E, Illouz S, Rahgoshay D, Burnett J, Holguin L, Chen PY, Ndjamen B, Ott M, Rodick R, Rogers T, Smith DM, Weinberger LS. Identfication of a therapeutic interfering particle-A single-does SARS-CoV-2 antiviral intervention with a high barrier to resistance. Cell. 2021 Dec 9;184(25):6022-6036.e18.

 

2. Ashhurst AS, Tang AH, Fajtová P, Yoon MC, Aggarwal A, Bedding MJ, Stoye A, Beretta L, Pwee D, Drelich A, Skinner D, Li L, Meek TD, McKerrow JH, Hook V, Tseng CT, Larance M, Turville S, Gerwick WH, O'Donoghue AJ, Payne RJ. Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. J Med Chem. 2021 Nov 3.

 

3. Jokerst J, Cheng Y, Borum RM, Clark AE, Jin Z, Moore C, Fajtová P, O'Donoghue AJ, Carlin AF. A Dual-Color Fluorescent Probe Allows Simultaneous Imaging of Main and Papain-like Proteases of SARS-CoV-2-Infected Cells for Accurate Detection and Rapid Inhibitor Screening. Angew Chem Int Ed Engl. 2021 Dec 9.

 

4. Jin Z, Mantri Y, Retout M, Cheng Y, Zhou J, Jorns A, Fajtova P, Yim W, Moore C, Xu M, Creyer M, Borum R, Zhou J, Wu Z, He T, Penny W, O'Donoghue AJ, Jokerst J. A Charge-Switchable Zwitterionic Peptide for Rapid Detection of SARS-CoV-2 Main Protease. Angew Chem Int Ed Engl. 2021 Dec 22.

 

5. Jin Z, Yeung J, Zhou J, Cheng Y, Li Y, Mantri Y, He T, Yim W, Xu M, Wu Z, Fajtova P, Creyer M, Moore C, Fu L, Penny W, O’Donoghue AJ, Jokerst J. Peptidic Sulfhydryl for Interfacing Nanocrystals and Subsequent Sensing of SARS-CoV‑2 Protease. ACS Chem Mater. 2022. In Press.

 

6. Cui Q, Garcia, G. Jr., Zhang M, Wang C, Li H, Zhou T, Sun G, Arumugaswami V, Shi Y. Compound screen identifies the small molecule Q34 as an inhibitor of SARS-CoV-2 infection iScience. 2021.

 

7. Luu AP, Yao Z, Ramachandran S, Azzopardi SA, Miles LA, Schneider WM, Hoffmann HH, Bozzacco L, Garcia G Jr, Gong D, Damoiseaux R, Tang H, Morizono K, Rudin CM, Sun R, Arumugaswami V, Poirier JT, MacDonald MR, Rice CM, Li MMH. A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry. Viruses. 2021 Oct 20;13(11):2113.

 

8. Chakravarty N, Senthilnathan T, Paiola S, Gyani P, Castillo Cario S, Urena E, Jeysankar A, Jeysankar P, Irudayam JI, Subramanian SN, Lavretsky H, Joshi S, Garcia Jr G, Ramaiah A, Arumugaswami V. Neurological pathophysiology of SARS-CoV-2 and pandemic potential RNA viruses: a comparative analysis. FEBS Lett. 2021;595(23):2854-71.

 

9. Wu B, Ramaiah A, Garcia Jr G, Hasiakos S, Arumugaswami V, Srikanth S. ORAI1 Limits SARS-CoV-2 Infection by Regulating Tonic Type I IFN Signaling. J Immunol. 2022;208(1):74-84

 

10. Foo SS, Cambou MC, Mok T, Fajardo VM, Jung KL, Fuller T, Chen W, Kerin T…..Arumugaswami V, Erzurum SC, Rao R, Jung JU, Nielsen-Saines K. The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2. Cell Rep Med. 2021;2(11):100453

 

11. Liu X, Verma A, Garcia G, Jr., Ramage H, Lucas A, Myers RL…Damoiseaux R, Arumugaswami V, Klein PS. Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition. Proc Natl Acad Sci U S A. Oct 19, 2021;118(42)

 

12. Cochrane WG, Fitzgerald PR, Paegel BM. Antibacterial Discovery via Phenotypic DNA-Encoded Library Screening. ACS Chem Biol. 2021. Nov 20;16, 2752–2756

13.  Huang Y, Harris BS, Minami SA, Jung S, Shah PS, Nandi S, McDonald K, Faller R. SARS-Cov-2 Spike binding to ACE2 is stronger and longer ranged with glycans. Biophys J. 2021 Dec 7:S0006-3495(21)03893-5.

 

14.  Petit MJ, Kenaston MK, Pham OH, Nagainis AN, Fishburn AT, Shah PS (corresponding author). Nuclear dengue virus NS5 antagonized expression of PAF1-dependent immune response genes. PLoS Pathog. 2021 Nov 19;17(11):e1010100

 

15. Kim HW, Wang M, Leber CA, Nothias LF, Reher R, Kang KB, van der Hooft JJJ, Dorrestein PC, Gerwick WH, Cottrell GW. A Deep Neural Network-Based Structural Classification Tool for Natural Products. J Nat Prod. 2021 Nov 22;84(11):2795-807

 

16. Kim HW, Zhang C, Cottrell GW, Gerwick WH. SMART-Miner: A convolutional neural network-based metabolite identification from (1) H-(13) C HSQC spectra. Magn Reson Chem. 2021 Dec 20

 

17. Benhamou RI,  Blessy Y, Tong WG, Cochrane V, Cavett S, Vezina-Dawod D, Abegg JL, Childs-Disney A,. Adibekian, Paegel BM, Disney MD. DNA-encoded library-versus-RNA-encoded library selection enables design of an oncogenic non-coding RNA inhibitor. PNAS 2022. In Press

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